About “GOOD ON” TIME

Are you optimizing your “Good On” time* with your current PD treatment?

Understanding the ups and downs of IR CD/LD

LEVODOPA LEVELS

Do you notice ups and downs with your IR CD/LD?

IR CD/LD has been the standard of care for treating PD for many years—it’s designed to work quickly but may wear off quickly too.

Ups and downs of IR CD/LD
  • Dyskinesia

    Dyskinesia happens when your medicine is working, but the level of levodopa is too high and you may experience movements you can’t control

  • “Good On” time and “On” time

    “Good On” time is when your medicine is working, and you are not experiencing dyskinesia or it is not troubling you.
    “On” time is when your medicine is working and your symptoms are well-controlled, but you may be experiencing troublesome dyskinesia

  • “Off” time

    “Off” time is when your medicine is not working and symptoms return

Ups and downs of IR CD/LD
  • Dyskinesia

    Dyskinesia happens when your medicine is working, but the level of levodopa is too high and you may experience movements you can’t control

  • “Good On” time and “On” time

    “Good On” time is when your medicine is working, and you are not experiencing dyskinesia or it is not troubling you.
    “On” time is when your medicine is working and your symptoms are well-controlled, but you may be experiencing troublesome dyskinesia

  • “Off” time

    “Off” time is when your medicine is not working and symptoms return

Over time with IR CD/LD, the duration of your symptom control may become more unpredictable, and you may experience more “Off” time. In fact, about half of patients taking a PD medication may experience “Off” episodes within 2 to 3 years of being on treatment

Tracking your “Good On” time* could be helpful

If you are noticing fluctuations with your IR CD/LD treatment, it could be helpful to track your “Good On” time,* “On” time, and “Off” time after each dose.

This information can not only be helpful for you, but it can also provide essential information when speaking with your doctor.

Footnotes

*“Good On” time is defined as “On” time without troublesome dyskinesia.

Indication & Important Safety Information

INDICATION

CREXONT® (carbidopa and levodopa) extended-release capsules is a prescription medication for the treatment of Parkinson’s disease, Parkinson’s disease caused by infection or inflammation of the brain, or Parkinson’s disease-like symptoms that may result from carbon monoxide or manganese poisoning in adults.

IMPORTANT SAFETY INFORMATION

Do not take CREXONT with antidepressant medications known as nonselective monoamine oxidase (MAO) inhibitors.

Do not take CREXONT with other carbidopa-levodopa preparations without consulting your healthcare provider.

CREXONT may cause falling asleep during activities of daily living, somnolence, or dizziness. Avoid activities that require alertness such as driving and operating machinery until you know how CREXONT affects you.

The most common side effects that may occur with CREXONT are nausea and anxiety.

It is important to avoid sudden discontinuation or rapid dose reduction of CREXONT. If you are discontinuing CREXONT, work with your healthcare provider to taper the dose over time to reduce the risk of fever or confusion.

You may take CREXONT with or without food, but taking it with food may decrease or delay its effect. Consider taking the first dose of the day about 1 to 2 hours before eating.

Swallow CREXONT whole. Do not chew, divide, or crush the capsules.

Do not take CREXONT with alcohol.

Tell your healthcare provider if you:

  • Have any heart conditions, especially if you have had a heart attack or irregular heartbeats
  • Experience hallucinations or abnormal thoughts and behaviors
  • Have an inability to control urges to gamble, have increased sexual urges, or experience other intense urges
  • Have thoughts of suicide or have attempted suicide
  • Have abnormal involuntary movements that appear or get worse during treatment
  • Have ever had a peptic ulcer or glaucoma
  • Become or intend to become pregnant. Based on animal data, CREXONT may cause fetal harm
  • Are breastfeeding during therapy

INDICATION

CREXONT® (carbidopa and levodopa) extended-release capsules is a prescription medication for the treatment of Parkinson’s disease, Parkinson’s disease caused by infection or inflammation of the brain, or Parkinson’s disease-like symptoms that may result from carbon monoxide or manganese poisoning in adults.

To report SUSPECTED ADVERSE REACTIONS, contact Amneal Specialty, a division of Amneal Pharmaceuticals, LLC at 1-877-835-5472 or the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please read the full Prescribing Information. For more information talk to your healthcare provider.

Indication & Important Safety Information

INDICATION

CREXONT® (carbidopa and levodopa) extended-release capsules is a prescription medication for the treatment of Parkinson’s disease, Parkinson’s disease caused by infection or inflammation of the brain, or Parkinson’s disease-like symptoms that may result from carbon monoxide or manganese poisoning in adults.

IMPORTANT SAFETY INFORMATION

Do not take CREXONT with antidepressant medications known as nonselective monoamine oxidase (MAO) inhibitors.

Do not take CREXONT with other carbidopa-levodopa preparations without consulting your healthcare provider.

CREXONT may cause falling asleep during activities of daily living, somnolence, or dizziness. Avoid activities that require alertness such as driving and operating machinery until you know how CREXONT affects you.

The most common side effects that may occur with CREXONT are nausea and anxiety.

It is important to avoid sudden discontinuation or rapid dose reduction of CREXONT. If you are discontinuing CREXONT, work with your healthcare provider to taper the dose over time to reduce the risk of fever or confusion.

You may take CREXONT with or without food, but taking it with food may decrease or delay its effect. Consider taking the first dose of the day about 1 to 2 hours before eating.

Swallow CREXONT whole. Do not chew, divide, or crush the capsules.

Do not take CREXONT with alcohol.

Tell your healthcare provider if you:

  • Have any heart conditions, especially if you have had a heart attack or irregular heartbeats
  • Experience hallucinations or abnormal thoughts and behaviors
  • Have an inability to control urges to gamble, have increased sexual urges, or experience other intense urges
  • Have thoughts of suicide or have attempted suicide
  • Have abnormal involuntary movements that appear or get worse during treatment
  • Have ever had a peptic ulcer or glaucoma
  • Become or intend to become pregnant. Based on animal data, CREXONT may cause fetal harm
  • Are breastfeeding during therapy

INDICATION

CREXONT® (carbidopa and levodopa) extended-release capsules is a prescription medication for the treatment of Parkinson’s disease, Parkinson’s disease caused by infection or inflammation of the brain, or Parkinson’s disease-like symptoms that may result from carbon monoxide or manganese poisoning in adults.

To report SUSPECTED ADVERSE REACTIONS, contact Amneal Specialty, a division of Amneal Pharmaceuticals, LLC at 1-877-835-5472 or the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please read the full Prescribing Information. For more information talk to your healthcare provider.